Protein World Fat Metaboliser Capsules Review

Fat Metaboliser Capsules are a product from UK based company Protein World. The product claims that it can help with tiredness and fatigue and contributes to normal metabolism. This review will aim to understand how the ingredients within this product can achieve this.



Pyridoxine hydrochloride is a form of Vitamin B6. The active form of vitamin B6 is known as P-L-P (1), which is stimulated by exercise (2). During exercise the body relies on the liver to produce glucose via glycogenolysis, for which vitamin b6 is essential for, and is an integral part of the glycogen phosphorylase enzyme and thus will provide energy to the bodies’ muscles (3).


Methylcobalamin is a form of Vitamin B12. Research studies on vitamin B12 have found that it is required for red blood cell production (4), protein synthesis and the repair and maintenance of tissue cells (5).

Caffeine Anhydrous

The suggested benefits of caffeine supplementation include the ability to attain greater use of fats as an energy source and sparing of muscle glycogen, (6). It has also been suggested that there is an increase of calcium release from the sarcoplasmic reticulum, which can create a greater muscle force production, (7). It has also been theorised that the effects of caffeine are probably exerted through effects upon the central nervous system or skeletal muscle by greater motor unit recruitment and alterations in neurotransmitter function (8).

Green Tea Extract

Green tea supplementation has been shown to have several health properties including an increase in plasma antioxidant which will lead to a lowering of oxidative damage (9, 10), decreased blood pressure (11, 12) and it can protect against coronary atherosclerosis (13). Other health effects that green tea can have includes a lowering of cholesterol, an increase of insulin activity (14) and a regulation of blood glucose levels which can help reduce body fat.


L-tyrosine is an amino acid which has been found to help produce adrenaline (15) and dopamine (16).

Guarana Extract

A main ingredient of guarana is caffeine; there have been several studies that have shown a significant increase weight loss with caffeine (17), but there have been few studies that have looked at the nutritional supplement on weight loss. Other studies of guarana have shown an increase of energy expenditure and fat oxidation of short periods of time which suggest that this could be due to a reduction in respiratory quotient and an increase in lipid oxidation (18).

Yerba Mate Powder

Yerba Mate’s origin is from the leaves of the South American plant ilex paraguariensis (19). The health benefits of this ingredient are numerous in amount. Yerba Mate acts as a powerful, high activity overall antioxidant (20). Other benefits include an increase in fat oxidation and gastric emptying as well as a shortening of perceived fullness all of which can aid in weight loss (21) and also contains hepatoprotective properties (22). Other weight loss benefits includes a lowering of cholesterol and delayed intestinal absorption of dietary fat (23). There is also evidence that Yerba Mate can have a stimulatory effect on the central nervous system (24) as well as benefits to the cardiovascular system (25).

Alpha Lipoic Acid

Alpha lipoic acid acts like B vitamins as it helps convert fats, carbohydrates and proteins into energy (26). It can also acts as a unique antioxidant because it is soluble in both water and lipids. This allows it to neutralize free radicals just about everywhere in the body, inside and outside the cells. It protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E (27).

Cayenne Powder

Cayenne Powder has properties that can aid in weight loss as it can act as a digestive aid by stimulating enzymes within the digestive tract which enables the body to metabolise food quicker and also decrease appetite (28). Another property of cayenne powder is that it contains capsaicin which helps alleviate pain (29).

Choline Bitartrate

Choline Bitartrate is choline combined with a chemical salt to help aid its absorption within the body. Choline is a water soluble nutrient that is naturally found within the body in small doses. The health benefits of choline are that it helps prevent fatty liver damage (30) as well as a lowering in cholesterol (31). It is used by athletes as it is believed to delay fatigue however some studies have shown this not to be the case (32).


The fat metaboliser capsules are claimed to help contribute to normal metabolism and help tiredness and fatigue. This product can achieve these claims with a massive part due to the high amount of caffeine within this product. The other ingredients within this product can also aid with the metabolism. This product should be consumed pre workout. This product has no banned substances when referring to the WADA prohibited list when observing the label / ingredients posted on the website.

*NOTE – This product has not been tested in a laboratory and may contain other substances that may not appear on the label


1 – Ubbink, J. B., Vermaak, W. J., van der Merwe, A., & Becker, P. J. (1993). Vitamin B-12, vitamin B-6, and folate nutritional status in men with hyperhomocysteinemia. The American journal of clinical nutrition, 57(1), 47-53.

2 – Manore, M. M. (2000). Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. The American journal of clinical nutrition, 72(2), 598s-606s.

3 – Manore, M. N., Leklem, J. E., & Walter, M. C. (1987). Vitamin B-6 metabolism as affected by exercise in trained and untrained women fed diets differing in carbohydrate and vitamin B-6 content. The American journal of clinical nutrition,46(6), 995-1004.

4 – d’Onofrio, G., Chirillo, R., Zini, G., Caenaro, G., Tommasi, M., & Micciulli, G. (1995). Simultaneous measurement of reticulocyte and red blood cell indices in healthy subjects and patients with microcytic and macrocytic anemia. Blood,85(3), 818-823.

5 – Fenech, M. (2001). The role of folic acid and vitamin B12 in genomic stability of human cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 475(1), 57-67.

6 – Costill, D. L., Dalasky, G. & Fink, W. (1978) Effects of caffeine ingestion on metabolism and exercise performance. Journal of Medicinal Science and sports exercise, 10 (3), 155–158.

7 – Tarnopolsky, M. A. (1994). Caffeine and endurance performance. Journal of Sports Medicine, 18(2), 109–125

8 – Bruce, C. R., Anderson, M. E. & Fraser, S. F. (2000). Enhancement of 2000-m rowing performance after caffeine ingestion. Journal of Medicine and Science in Sports and Exercise, 32 (11), 1958–1963.

9- Rietveld, A., & Wiseman, S. (2003). Antioxidant effects of tea: evidence from human clinical trials. The Journal of nutrition, 133(10), 3285S-3292S.

10 – McKay, D. L., & Blumberg, J. B. (2002). The role of tea in human health: an update. Journal of the American College of Nutrition, 21(1), 1-13.

11 – Yang, Y. C., Lu, F. H., Wu, J. S., Wu, C. H., & Chang, C. J. (2004). The protective effect of habitual tea consumption on hypertension. Archives of internal medicine, 164(14), 1534-1540.

12 – Hodgson, J. M., Devine, A., Puddey, I. B., Chan, S. Y., Beilin, L. J., & Prince, R. L. (2003). Tea intake is inversely related to blood pressure in older women. The Journal of nutrition, 133(9), 2883-2886.

13 – Sasazuki, S., Kodama, H., Yoshimasu, K., Liu, Y., Washio, M., Tanaka, K., … & Takeshita, A. (2000). Relation between green tea consumption and the severity of coronary atherosclerosis among Japanese men and women. Annals of epidemiology, 10(6), 401-408.

14 – Anderson, R. A., & Polansky, M. M. (2002). Tea enhances insulin activity. Journal of Agricultural and Food Chemistry, 50(24), 7182-7186.

15 – Boylen, J. B., & Quastel, J. H. (1961). Effects of L-phenylalanine and sodium phenylpyruvate on the formation of adrenaline from L-tyrosine in adrenal medulla in vitro. Biochemical Journal, 80(3), 644.

16 – Mannironi, C. E. C. I. L. I. A., Scerch, C. H. I. A. R. A., Fruscoloni, P. A. O. L. O., & Tocchini-Valentini, G. P. (2000). Molecular recognition of amino acids by RNA aptamers: the evolution into an L-tyrosine binder of a dopamine-binding RNA motif. Rna, 6(4), 520-527.

17 – White, LM,, Gardner, SF, Gurley, BJ, Marx, MA, Wang, PL, Estes, M. (1997). Pharmacokinetics and cardiovascular effects of Ma huang (ephedra sinica) in normotensive adults. Journal of clinical pharmacology. 37, 116-122.

18 – Be´rube´-Parent S, St-Pierre S, Prud’homme D, Doucet E, Tremblay A. (2001). Obesity treatment with a progressive clinical tri-therapy combining sibutramine and a supervised diet–exercise intervention. International Journal of Obesity. 25, 1144–1153.

19 – Heck, C. I., & De Mejia, E. G. (2007). Yerba Mate Tea (Ilex paraguariensis): a comprehensive review on chemistry, health implications, and technological considerations. Journal of Food Science, 72(9), R138-R151.

20 – Bracesco, N., Dell, M., Rocha, A., Behtash, S., Menini, T., Gugliucci, A., & Nunes, E. (2003). Antioxidant activity of a botanical extract preparation of Ilex paraguariensis: prevention of DNA double-strand breaks in Saccharomyces cerevisiae and human low-density lipoprotein oxidation. The Journal of Alternative & Complementary Medicine, 9(3), 379-387. 

21 –Dickel, M. L., Rates, S. M. K., & Ritter, M. R. (2007). Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil. Journal of ethnopharmacology, 109(1), 60-71.

22 – Filip, R., & Ferraro, G. E. (2003). Researching on new species of “Mate”: Ilex brevicuspis. European journal of nutrition, 42(1), 50-54.

23 – Martinet, A., Hostettmann, K., & Schutz, Y. (1999). Thermogenic effects of commercially available plant preparations aimed at treating human obesity.Phytomedicine, 6(4), 231-238.

24 – Gonzalez, A., Ferreira, F., Vazquez, A., Moyna, P., & Paz, E. A. (1993). Biological screening of Uruguayan medicinal plants. Journal of ethnopharmacology, 39(3), 217-220.

25 – Schinella, G., Fantinelli, J. C., & Mosca, S. M. (2005). Cardioprotective effects of Ilex paraguariensis extract: evidence for a nitric oxide-dependent mechanism.Clinical Nutrition, 24(3), 360-366.

26 – Data, P. (1995). Alpha-Lipoic Acid. Arzneimittelforschung, 45, 872-874.

27 – Packer, L., Witt, E. H., & Tritschler, H. J. (1995). Alpha-lipoic acid as a biological antioxidant. Free Radical Biology and Medicine, 19(2), 227-250.

28 – Hastings, C. W., & Barnes, D. J. (1997). U.S. Patent No. 5,626,849. Washington, DC: U.S. Patent and Trademark Office.

29 – Berger, A., Henderson, M., Nadoolman, W., Duffy, V., Cooper, D., Saberski, L., & Bartoshuk, L. (1995). Oral capsaicin provides temporary relief for oral mucositis pain secondary to chemotherapy/radiation therapy. Journal of pain and symptom management, 10(3), 243-248.

30 – Lombardi, B., Pani, P., & Schlunk, F. F. (1968). Choline-deficiency fatty liver: impaired release of hepatic triglycerides. Journal of lipid research, 9(4), 437-446.

31 – De Miguel, I., Roueche, A., & Betbeder, D. (1999). Separation of dipalmitoyl phosphatidyl choline, cholesterol and their degradation products by high-performance liquid chromatography on a perfluorinated stationary bonded phase. Journal of Chromatography A, 840(1), 31-38.

32 – Spector, S. A., Jackman, M. R., Sabounjian, L. A., Sakkas, C. A. L. L. I., Landers, D. M., & Willis, W. T. (1995). Effect of choline supplementation on fatigue in trained cyclists. Medicine and science in sports and exercise, 27(5), 668-673.

Use for  Weight Loss
Price  £12.99